The Roboenza Virus is an robot-infecting disease that appears in the Mega Man comic series published by Archie Comics. Similar to the real-life influenza disease, this virus spreads among only robots, which can cause the robots to go on rampages.
The Roboenza Virus is only mentioned in Mega Man #20, where Roll was affected by the disease. Although the whole story of the spreading of the disease nor the adaption of Mega Man 10 was not told due to the limitations of the story in Mega Man #20, Mega Man and Proto Man would have gone out to find the cure for the disease and to stop the Roboenza-infected Robot Masters–Blade Man, Pump Man, Commando Man, Chill Man, Sheep Man, Strike Man, Nitro Man, and Solar Man.
- Roboenza is a portmanteau of the words "robot" and "influenza", given that it is a robotic disease that acts similar to the latter.